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【About girl】Hormonal Functions of the Female, Hormonal control of the menstrual cycle

Female hormone

【About girl】Hormonal Functions of the Female,  Hormonal control of the menstrual cycle

The understanding reproductive and hormonal function of females is essential as it involves in many ovaries diseases and some physiology functions. On the basis of understanding, carry on body care and love yourself to prevent disease.

This blog will briefly introduce functions of each hormone in female and hormonal control of the menstrual cycle.

Content:

1. Menstruation cycle or female sexual cycle
2. Hormone in Female
    a. Gonadotropin-releasing hormone (GnRH)
    b. Follicle-stimulating hormone (FSH)
    c. Luteinizing hormone (LH)
    d. Estrogens
    e. Progesterone
    f. Testosterone
    g. Oxytocin
    h. Arginine Vasopressin
    i. Human Chorionic Somatommotropin (HCS)
        Difference between Oxytocin and Arginine Vasopressin
3. Hormonal control of the menstrual cycle 


1. Menstruation cycle or female sexual cycle

1. Uterine cycle

  • the preparation and maintenance of the lining of the uterus (womb) to receive a fertilized egg.
  • Phase:
    • Proliferative phase (estrogen phase)
    • Secretary phase (progesterone phase)
    • Menstruation

Uterine cycle


2. Ovarian cycle

  • controls the production and release of eggs and the cyclic release of estrogen and progesterone. 
  • Phase:
    • Follicular phase
    • Ovulation
    • Luteal phase

Ovarian cycle

2. Hormone in Female

The stages of the ovarian cycle in the female are regulated by hormones secreted by the hypothalamus, pituitary, and ovaries.

a. Gonadotropin-releasing hormone (GnRH)

  • Stimulates luteinizing hormone (LH), which in turn stimulate the reproductive functioning of the ovaries and testes 
  • Stimulates gonadotrophs (G) to release follicle-stimulating hormone (FSH) 


More about the "Pituitary Hormone": 【Pharmacology】Drugs for pituitary and thyroid disease 


b. Follicle-stimulating hormone (FSH)

  • Stimulates the development of egg cells (ova), which develop in structures called follicles.
  • Regulate: Follicle cells produce the hormone inhibin, which inhibits FSH production. 


c. Luteinizing hormone (LH)

  • Stimulates the development of egg cells (ova), as well as in the induction of ovulation
  • Stimulation of estrogens and progesterone production by the ovaries
  • Regulate: Progesterone assists in inhibition of FSH and LH release


Hormone in menstrual cycle:

d. Estrogens

  • Major female hormone
  • Assists in endometrial regrowth, ovulation, and calcium absorption
  • Responsible for the secondary sexual characteristics of females
    • breast development
    • flaring of the hips
    • bone maturation
  • Increases sexual desire
    • Having higher levels of estrogen in the body promotes vaginal lubrication and increases sexual desire
  • Normal range:
    • Adult female, premenopausal: 15-350 pg/mL
    • Adult female, postmenopausal: <10 pg/mL
    • Adult male: 10-40 pg/mL

e. Progesterone

  • Assists in endometrial regrowth
    • prepares the endometrium for the potential of pregnancy after ovulation. 
    • triggers the lining to thicken to accept a fertilized egg.
    • prohibits the muscle contractions in the uterus that would cause the body to reject an egg
  • Stimulates the growth of milk ducts in the breasts
  • Increases core temperature (thermogenic function) during ovulation
  • Normal range:

Progesterone normal range


Other hormone:

f. Testosterone

  • Small amounts of testosterone come from the adrenal glands and ovaries
  • Sexual desire
  • Regulation of the menstrual cycle
  • Bone and muscle strength
  • Normal range for females is 15 to 70 nanograms per deciliter (ng/dL).

g. Oxytocin

  • contraction of the womb (uterus) during childbirth and lactation.
  • increases production of prostaglandins, which increase the contractions further.

h. Arginine Vasopressin

  • promotes the reabsorption of water from the tubular fluid in the collecting duct
  • increases blood flow to the heart and brain
  • may cause dysmenorrhea

i. Human Chorionic Somatommotropin (HCS)

  • stimulates growth of fetus 
  • regulates metabolism of carbohydrate, fat and protein in both the fetus and the mother

Difference between Oxytocin and Arginine Vasopressin

Both can cause dysmenorrhea, but

Difference between Oxytocin and Arginine Vasopressin


Learn more about dysmenorrhea: 【About Girl】经痛 Dysmenorrhea


3. Hormonal control of the menstrual cycle 

Follicular phase: FSH level are initially high to develop follicles before being inhibited by estrogen production

Ovulation: A huge spike in LH levels and to a lesser extent, FSH, triggers ovulation to release of an ova.

Luteal phase: Rising levels of estrogen and progesterone inhibit both FSH and LH. Hence, FSH and LH levels decrease.

Menstruation: When the corpus luteum degenerates, estrogen and progesterone levels fall and FSH levels rise.

Hormonal control of the menstrual cycle (Ovarian cycle)


Each Phase:

Hormonal control of the menstrual cycle (Ovarian cycle) each phase


Related link:
A storyline about menstrual cycle: 【About girl & Pharmacology】Hormonal Contraceptives

The formation of menstruation  (Chinese): 【About Girl】经痛 Dysmenorrhea

4. Reference:

https://www.healthline.com/health/female-sex-hormones#hormonal-changes

https://www.frontiersin.org/articles/10.3389/fendo.2017.00134/full



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