Medical student's note

 Major cytokines in inflammation CYTOKINE CELL SOURCE CELL TARGET MAIN ACTIONS IL-1 Monocytes/macrophages, B cells, fibroblasts, endothelial cells, some epithelial cells All cells • Expression of adhesion molecules • Emigration of neutrophils and macrophages • Role in fever and shock • Hepatic production of acute phase protein IL-6 Same as for IL-1 T and B cells, Epithelial cells, hepatocytes, Monocytes/macrophages • Hepatic production of acute phase protein • Differentiation and growth of T and B cells IL-8 Monocytes/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, epithelial cells Neutrophils, basophils, T cells, monocytes/macrophages, endothelial cells • Induces migration of neutrophils, macrophages and T cells • Stimulates relea

 Morphology and functions of inflammatory cells MORPHOLOGY FEATURES MEDIATORS A, POLYMORPH ·          Initial phagocytosis of bacteria and foreign body ·          Acute inflammatory cell ·          Primary granules (MPO, lysozyme, cationic proteins, acid hydrolases, elastase) ·          Secondary granules (lysozyme, alk. phosph, collagenase, lactoferrin) ·          Tertiary granules (gelatinase, cathepsin) ·          Reactive oxygen metabolites B, MONOCYTE/MACROPHAGE ·          Bacterial phagocytosis ·          Chronic inflammatory cell ·          Regulates lymphocyte response ·          Acid and neutral hydrolases (lysosomal) ·          Cationic protein ·          Phospholipase ·          Prostaglandins, leukotrienes ·